What is NAD + Infusion

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NAD+ stands for nicotinamide adenine dinucleotide. From single-cell organisms like bacteria to sophisticated multicellular ones like primates, NAD+ is one of the most abundant and crucial molecules. Basically, without NAD+, we would be on the fast track to death. The molecule is a linchpin to the function of the generators of cells — mitochondria. NAD+ not only helps convert food to energy but also plays a crucial role in maintaining DNA integrity and ensures proper cell function to protect our bodies from aging and disease.

NAD+ works as a shuttle bus, transferring electrons from one molecule to another within cells to carry out all sorts of reactions and processes. With its molecular counterpart, NADH, this vital molecule participates in various metabolic reactions that generate our cell’s energy. Without sufficient NAD+ levels, our cells wouldn’t be able to generate any energy to survive and carry out their functions. Other functions of NAD+ include regulating our circadian rhythm, which controls our body’s sleep/wake cycle.

As we age, NAD+ levels fall, suggesting important implications in metabolic function and age-related diseases. DNA damage accumulates and snowballs with aging.

Numerous studies demonstrate reduced NAD+ levels in disturbed nutrient conditions, such as obesity, and aging. Reductions in NAD+ levels can lead to problems with metabolism. These problems can lead to disorders, including obesity and insulin resistance. Obesity causes diabetes and high blood pressure.

Metabolic disorders caused by the low NAD+ level cascade down. High blood pressure and other heart function decline can send damaging pressure waves to the brain that may lead to cognitive impairment.

Targeting NAD+ metabolism is a practical nutritional intervention in protecting against metabolic and other age-related diseases. Several groups have done studies indicating supplementing with NAD+ boosters improves insulin resistance from obesity. In mouse models of age-related diseases, supplementing with NAD+ boosters improves symptoms of the diseases. This suggests reduced NAD+ levels with age may contribute to the onset of age-related diseases.

Preventing the decline of NAD+ offers a promising strategy to combat metabolism disorders with age. As NAD+ levels decrease with age, this can lead to reduced DNA repair, cellular stress response, and regulation of energy metabolism.

NAD+ is important for species’ mitochondrial maintenance and gene regulation regarding aging. However, the level of NAD+ in our body declines drastically with age. “As we get older, we lose NAD+. By the time you’re 50, you have about half the level you once had when you were 20,” says David Sinclair of Harvard University in an interview.

Studies have shown the decrease of the molecule associates with age-related diseases including accelerated aging, metabolic disorders, heart disease, and neurodegeneration. Low levels of NAD+ is associated with age-related disease due to less functional metabolism. But replenishing NAD+ levels has presented anti-aging effects in animal models, showing promising results in reversing age-related diseases, increasing lifespan and healthspan.